Brain inflammation is a common problem for our kids and can be challenging to treat. Children on the spectrum often have chronic autoimmune processes. Neopterin is a good biomarker for this. High neopterin = inflammation and, in the absence of infection, suggests autoimmunity issues.
He also suggested some non-invasive biomarkers for inflammatory bowel disease or similar conditions. In particular, he suggested calprotectin as the biomarker that shows the strongest correlations with bowel conditions. Genova Diagnostics can run this test.
Dr. Bradstreet noted that differences between individuals' microbiotia influence not only our health risks but may also help explain why individuals respond differently to interventions.
Dr. Bradstreet noted that recent research has shown that, in one study, 11.5% of mothers of children with autism have reactivity against fetal brain (but not adult) without similar numbers in the control groups. The cause is not known at this time but may potentially be viral. This reactivity may also play a role in families with multiple children on the spectrum, but this requires more research to determine the connection, if any.
Dr. Bradstreet also said that while we know that many of our children have oxidative stress issues, we should test ourselves too. Many parents have increased RNA oxidation which increases our risk for early onset Alzheimer's Disease and Parkinson's Disease. We also are at greater risk for autoimmune diseases.
Dr. Bradstreet reminded us to take care of ourselves as well as our children.